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Dipeptide-SWCNTs-based Supramolecular Hybrid Hydrogel
Subhasish Roy*

Prayogic Rasayan 2021, 5(3), 76-81

DOI: https://www.doi.org/10.53023/p.rasayan-20211111


A dipeptide appended pyrenebutyric acid's amide forms hydrogel at basic pH with an estimated minimum gelation concentration of 0.29 % w/v. The hydrogel was characterized by using various microscopic and spectroscopic techniques. The gelator molecule itself can disperse pristine-single walled carbon nanotubes (SWCNTs) in basic aqueous medium and it can also form a hybrid hydrogel with SWCNTs. Fluorescence, morphological and rheological properties of the hybrid hydrogel were different from the native hydrogel.

Biopolymer-based Films and Coatings: Emerging Technologies to Extend Shelf-life of Fruits and Vegetables
L. Susmita Devi, Manashi Das Purkayastha, Avik Mukherjee, Santosh Kumar*

Prayogic Rasayan 2021, 5(3), 82-91

DOI: https://www.doi.org/10.53023/p.rasayan-20211211


Numerous published reports have demonstrated that biopolymer-based films and coatings can effectively reduce weight loss, and postharvest decay such as biochemical and microbial spoilage of coated fresh fruits and vegetables resulting in their postharvest shelf-life extension by a few days to as long as a month. This review is a comprehensive account on applications of biopolymer based active, composite coatings and films for sustainable packaging of fresh produce.

A short review on synthesis of dihydrophenanthrene, phenanthrene and its analogues by palladium-catalyzed reaction
Mitali Dewan, Rathin Jana*

Prayogic Rasayan 2021, 5(3), 93-101

DOI: 10.53023/p.rasayan-20211214


Use of transition metal compounds or complexes as catalysts or reagents in organic synthesis is an exciting field in research and numerous novel reactions which are impossible to achieve by conventional synthetic methods have already been discovered. Palladium catalysed C-C bond forming reaction is very important for the synthesis of carbocyclic compounds. In this mini review we have reviewed of some efficient methods for the construction of a dihydrophenanthrene, phenanthrene and its analogues by palladium-catalyzed reaction.

Targeting COVID-19 (SARS-CoV-2) RNA dependent RNA polymerase through active phytochemicals of ayurvedic medicinal plants Limonia acidissima Linn. And Ocimum sanctum: A molecular docking study
Avishek Ghosh,* Putul Karan

Prayogic Rasayan 2021, 5(3), 102-108

DOI: https://www.doi.org/10.53023/p.rasayan-20211216


Virtual screening of phytochemicals was performed through molecular docking to identify the potential hits that can inhibit the effects of SARS-CoV-2. Considering the published literature on medicinal importance, the phytochemicals from tulsi and wooden apple were selected to search potential inhibitors for RdRp (RNA dependent RNA polymerase) of SARS-CoV-2. The in silico computational results revealed that the phytochemicals such as Limonin, Obacunone, Rutaevin,(-)-(2S)-5,3'-Dihydroxy-4'-methoxy-6",6"-dimethylchromeno-(7,8,2",3")-flavanone, Lupeol, 5-Hydroxy-2-(-hydroxyphenyl)-7-methoxy-6-(3-methylbut-2-enyl)chroman-4-one, Vitexin, Orientin, and Urosolic acid were found to be effective against the target RdRp (RNA dependent RNA polymerase) of SARS-CoV-2. The protein-ligand interaction study revealed that these phytochemicals bind with the amino acid residues at the active site of the target proteins with a higher binding affinity than remdesivir. Therefore, the core structure of these potential hits can be used for further lead optimization to design drugs for SARS-CoV-2. Also, the medicinal plants containing these phytochemicals like tulsi and wooden apple can be used to formulate suitable therapeutic approaches in traditional medicines.