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Multiple pathways employing Proton-Coupled Electron Transfer (PCET) have been demonstrated for the synthesis of dimerized 3-Oxindoles.

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Molecular pathways for technologically important tin chalcogenide nanostructures
Gourab Karmakar,a Adish Tyagi,*a,b

Prayogic Rasayan 2024, 8(2), 22-29

DOI: https://www.doi.org/10.53023/p.rasayan-20240830

Keywords: Single Source Molecular Precursor, Tin Chalcogenide, Nanomaterials, Thin Films, Energy Application.

Tin chalcogenides have been projected as promising energy materials owing to their interesting physico-chemical properties. It is needed to evolve a cost effective route to fully harvest their commercial potential. Single source molecular precursors (SSP) offer a versatile route to functional materials. This mini review is intended to summarize various SSPs reported so far for tin chalcogenides. The effect of different ligand systems, capping agents in modulating the properties of tin chalcogenides have been discussed. Finally, the applications of SSP derived tin chalcogenides have also been included in this account.


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Evaluation of Aloe vera (L.) in Mitigating Diabetes-Induced Oxidative Stress Linked Testicular Dysfunction
Debidas Ghosh* and Dibya Pal

Prayogic Rasayan 2024, 8(2), 30-37

DOI: https://doi.org/10.53023/p.rasayan-20240908

Keywords: Diabetes, Male infertility, Aloe vera (L.), Oxidative stress, Apoptosis, Spermiological sensor

Diabetes is associated with male infertility. The ex-vivo and in-vivo studies focused that Aloe vera (L.) hydro-ethanol extract can recover significantly sperm motility, viability, plasma membrane integrity, apoptosis and DNA fragmentation from diabetic state. Serum insulin, c-peptide and testosterone levels were also recovered by the extract, reflected in histological study of pancreas and testis along with genomic study of androgenic key enzymes in diabetic state.


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Multiple Routes for the Synthesis of Dimerized 3-Substituted-2-Oxindoles Employing Proton-Coupled Electron Transfer
Harapriya Behera, Shivani Ahlawat, and Amit Paul*

Prayogic Rasayan 2024, 8(2), 38-43

DOI: https://doi.org/10.53023/p.rasayan-20240912

Keywords: Dimerization, Proton-Coupled Electron Transfer, Hydride Transfer, 3-Substituted-2-Oxindole

We discussed four different synthetic routes for the dimerization of 3-carboxylate-2-oxindole (1a). The order of efficiency was: Stepwise electron transfer (ET)-proton transfer (PT) Stepwise-ET-PT-ET Stepwise-PT-ET-ET TEMPO+-catalyzed hydride (H-) (2e- & H+) transfer. We also discussed dimerization of 3-alkyl-2-oxindole (4a), which followed a kinetically slower TEMPO+-catalyzed 1e- transfer mechanism, since pKa of pseudobenzylic proton of 4a is significantly higher than that of 1a.