Aromatic acids are feedstock molecules and their site-selective transformations employing the C-H bond provide a convenient avenue to assemble high-value molecular scaffolds. In this account article, we showcased a variety of ruthenium(II) catalyzed C-H bond activation and functionalization reactions of benzoic acids developed by our research group. Challenges in reaction design and mechanistic rationale were critically discussed for a comprehensive understanding.
Recent Developments in RAFT Derived Side-Chain Amino Acid-Based
Polymers for Biological Applications
Tamanna Mallick, Puja Poddar, Kundan Patel and Priyadarsi De*
Polymers with pendant amino acid moieties play a crucial role in shaping the properties of the resultant material, presenting captivating attributes like customizable amphiphilicity, chiral induction, organocatalytic capabilities, biocompatibility, aqueous solubility, and the ability to self-assemble into complex hierarchical structures. This review article aims to highlight the recent developments in the synthesis and utilization of these polymers, encompassing a range of current, high-demand applications such as drug and gene delivery, antibacterial activity, fibril inhibition, and biomimetic catalysts.
We have reported the design, synthesis and gelation study of Leu-Phe peptide-mimetic
1-mimetic with 4-terphenylcarboxy protecting group at the N-terminus and C-terminus
as methyl ester. The Suzuki-Miyaura cross-coupling reaction of biphenyl boronic acid
and 4-bromo benzoic acid in presence of Pd(OAC) 2 , urea and sodium carbonate in
water results the p-terphenyl-4-carboxylic acid in excellent yield. The peptide-mimetic 1
in methanol solution show emission band at 380 nm on excitation at 292 nm.
Interestingly, the peptide-mimetic 1 formed organogel in different organic solvents such
as toluene, xylene, chlorobenzene, acetonitrile, nitromethane with minimum gelation
concentration 5 mg/mL. However, the peptide-mimetic 1 fails to form organogel in
hexane, DCM, EtOAc, MeOH, EtOH under same condition. The peptide-mimetic 1
based gels have high stability. From rheology study, the storage modulus of the
organogel was approximately an order of magnitude larger than the loss modulus,
which indicates the physical crosslink and the elastic nature of the gel. FESEM image of
that xerogel exhibits entangled fiber network morphology. The gel may be use for
removal of dyes from contaminated water. The maximum amount of Rhodamine 6G
absorbed by gel is 4.5 mg/ g of gel.
