1,5-diazabicyclo[3.3.0]octadienediones, also known as bimanes, are heterobicyclic compounds with generally high quantum yields, low toxicity, and low molecular weight. During the 1970s, the bimane fluorophore, which was synthesized from the reaction of a beta-keto ester and hydrazine, was first reported by Kosower and co-workers. Since that time, significant effort has been invested in the introduction of functional groups at the alpha-positions of syn-bimane, the bimane isomer in which both carbonyl groups are oriented in the same direction. In spite of these efforts, the successful attachment of high value functional groups at the alpha-positions of syn-bimane remain scarce. A recent report from Prof. Flavio Grynszpan's group using a solvent-free, environmentally friendly (i.e. "green") method allowed for a rapid, large-scale synthesis of bimane and the preparation and study of differently-substituted bimane derivatives. In this review, we describe the advantages of the current green synthesis of bimanes and the applications of the newly formed bimane derivatives as fluorescent and colorimetric sensors, with special attention paid to the relationship between the bimane structures, their photophysical characteristics, and their performance as chemical sensors.

Marigold is a hardy annual herb native to Southern Europe and is also cultivated extensively in Asia, India, China and other countries with a tropical climate. Marigold flowers have different fragrances and colors, in which the yellow color is most common.These flowers are edible and also used as colouring agent and spice. A yellow dye obtained from the flower can be used as a spice substitute for colouring and flavouring foods. Lutein is an oxycarotenoid or xanthophylls, it is one of the major constituents and the main pigment of Tagetes erecta species. A variety of chemical constituents have been isolated from Tagetes species.They are essential oils, carotenoids, flavonoids, terpenoids, thiophenes and phenolic compounds.The important phytochemical constituents present in the different part of the plants are lutein, quercetin, quercetagetin, a glucoside of quercetagetin, syringic acid, thienyl, terpines and phenolic copounds. The leaves are used against muscular-pain, piles, ulcers, wounds and kidney troubles. The flowers are useful in fevers, epileptic, stomachic , astringent, scabies, carminative, liver and eyes diseases.The plant exhibites different pharmacological activities like anti-bacterial, anti-microbial, anti-oxidant, analgesic, hepatoprotective, insecticidal, mosquitocidal, Larvicidal and wound healing activity. It is also used as drug from ancient times in the india for the treatment of cold, rheumatism, bronchitis, ulcers, eye diseases, purify the blood, bleeding, piles etc.