The study was carried out to investigate the in vitro thrombolytic potential of crude methanolic extract of flowers of Nerium oleander, a plant widely employed in traditional medicine to treat cardiovascular diseases. Using the blood of selected sixteen individuals, the thrombolytic activity was assessed in four different concentrations of the crude plant extract where streptokinase and normal saline were used as the positive and negative control respectively. The clot lysis percentage was calculated using weight reduction of the blood clot in comparison to the initial clot weight. The highest thrombolytic potential was observed at 10 mg/mL concentration of the extract and there was no significant difference between mean clot lysis percentages of streptokinase and this extract. Therefore, 10.0 mg/mL concentration of methanolic extract of flowers of N. oleander has a good thrombolytic ability, however, further investigations on its chemical profile and toxic properties are required before developing it as a therapeutic agent.

Among the less-studied plants, Paederia foetida (commonly known as Gandal) has been used by various ethnic tribes as food and medicine. The phytochemicals present in the leaf extract of Paederia foetida were utilized for the green synthesis of Paederia foetida conjugated gold nanoparticles (PF-AuNPs). Characterization of PF-AuNPs was carried out by SPR absorption band, HRTEM, DLS and X-ray diffraction studies. Anticancer activity of the stabilized PF-AuNPs studied against MCF-7 breast cancer cell line and HeLa cell lines revealed that the stabilized PF-AuNPs were highly effective for the apoptosis of cancer cells selectively. Catalytic activity of PF-AuNPs has also been reported.