VOL-1 ISSUE-2, July 2017


Serial NoTitle & Author NameViewsDownloads
1.A bioactive diterpene; Nasimalun A from Croton oblongifolius Roxb.

By Kanchana Wijesekera

Pages : 41-44


A clerodane type diterpene, nasimalun A was isolated from a dichloromethane extract of the leaves of Croton oblongifolius Roxb. Nasimalun A showed moderate cytotoxicity toward MOLT- 3 cell line with IC50 value of 26.44 µg/mL. Furthermore, nasimalun A showed minimum inhibitory concentration (MIC) of 50, 12.5, and100 μg/mL for Bacillus cereus and both Staphylococcus aureus, and Staphylococcus epidermidis respectively.


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2.Glucocorticoid receptor: A potent cellular & gene therapy target for cancer and cancer stem cells

By Rajkumar Banerjee

Pages : 45-47


Glucocorticoid receptor (GR) is expressed in the cytoplasm of almost all cells, if not all of cancer and non-cancer cells. Moreover, unlike many other factors implicated with cancer, it is neither over-expressed nor is it expressed on cell-membrane surface to qualify logically as a viable target for treating cancer.


552415
3.Study of Antioxidant Property of the Endosperm Extract of Borassus flabellifer (Taal) and its use in the green synthesis of Gold nanoparticles

By Sk Nurul Hasan and Braja Gopal Bag

Pages : 48-52


The antioxidant activity of the endosperm extract of Borassus flabellifer (commonly known as Taal) has been studied against a long lived 2,2-diphenylpicrylhydrazyl (DPPH) radical at room temperature. The phytochemicals present in the endosperm extract have been utilized for the synthesis of stable gold nanoparticles at room temperature under very mild conditions.


691488
4.Study of Antioxidant Property of the Rhizome Extract of Polygonatum cirrhifolium (Mahameda) and its use in the green synthesis of Gold nanoparticles

By Braja Gopal Bag, Shib Shankar Dash and Anup Mandal

Pages : 53-57


The antioxidant efficacy of the rhizome extract of Polygonatum cirrhifolium (Mahameda) has been studied against a stable 2, 2-diphenylpicrylhydrazyl (DPPH) radical at room temperature. The chemical constituents present in the rhizome extract have been utilized for the one step synthesis of stable gold nanoparticles at room temperature under very mild conditions.


624492
5.Synthetic studies of antascomicin A: Construction of C1-C16 fragment

By Jithender Reddy Vakiti and Subhash Ghosh

Pages : 58-60


This communication describes the stereoselective synthesis of C1-C16 fragment of antascomicin A, a non-immunosuppressive immunophil-binding natural product. Evans aldol reaction was used extensively to install all the stereo centres present in the fragment. The hemikatel present in the fragment was synthesized via DMP-mediated oxidation of -hydroxy amide followed by acid catalyzed hemiketalization.


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