VOL-2 ISSUE-2, April 2018

Determination of critical vesicular concentration (cvc) of nano-sized oleanolic acid by using hydrophobic pyerene as a fluorescence probe

Pages : 5-8

Author(s) : Saikat Kumar Panja, Kanchana Dilrukshi Wijesekera, Mayuri Tharanga Napagoda, Braja Gopal Bag

Category : Research Paper

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Abstract :
Previously we have reported the spontaneous self-assembly of renewable nano-sized oleanolic acid in aqueous-organic binary solvent mixtures to form vesicles (B. G. Bag and K. Paul, Asian J. Org. Chem., 2012, 1, 150 – 154). Herein, we report the critical vesicular concentration (cvc) of oleanolic acid in DMSO-Water at varied ratio. The cvc’s determined by fluorescence spectrophotometry using hydrophobic pyrene as a fluorescence probe in 2:1, 1:1 and 1:4 DMSO-water mixture were 83, 73, 47 micro-molar respectively. The cvc values were comparable with the corresponding data of arjunolic acid.

Keywords : Oleanolic acid, vesicle, cvc, pyrene, fluorescence